2 edition of Characterization of the P2u purinoceptor in pheochromocytoma (PC12) cells. found in the catalog.
Characterization of the P2u purinoceptor in pheochromocytoma (PC12) cells.
Written in English
|The Physical Object|
|Number of Pages||172|
Imaging tests are used to assess the location of a pheochromocytoma or paraganglioma. For some of the imaging studies,, it is the requirement of the radiology department that within seven days of any imaging studies (scan) you will be required to have your blood drawn. A pheochromocytoma is a rare, catecholamine-secreting tumor derived from chromaffin cells. The term pheochromocytoma (in Greek, phios means dusky, chroma means color, and cytoma means tumor) refers to the color the tumor cells acquire when stained with chromium salts.
We suggest that the P2u purinoceptor is likely to be responsible for mucin release by these nucleotides, probably via activation of phospholipase C. Discover the world's research 17+ million members. Entry name i: P2RY2_HUMAN: Accession i: P Primary (citable) accession number: P Secondary accession number(s): B2R9W3, Q96EM8: Entry history i: Integrated into UniProtKB/Swiss-Prot:: February 1, Last sequence update:: November 2, Last modified:: Ap This is version of the entry and version 4 of the sequence. See complete history.: Entry status i.
RT-PCR was performed on 31EG4 cells grown to confluence in the presence of dexamethasone to increase differentiation of the cells. The PCR experiment summarized in Fig. 1 shows that mRNA for the P2Y 2 purinoceptor is present in 31EG4 cells. Fig. product for the P2Y 2 purinoceptor ( bp). The amplified product was run on a % agarose Cited by: It is concluded that the Ca2+ release from discrete stores of C2C12 myotubes is induced by stimulation of nAChRs, P2U-purinoceptors and by high K+. Only the P2U-purinoceptor and nAChR activated stores show considerable overlap in releasable Ca2+.Cited by:
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Micromolar levels of extracellular ATP increased cytosolic Na+ concentration ([Na+]i) as well as cytosolic Ca2+ concentration ([Ca2+]i) in PC12 cells. Pretreatment of cells with tetrodotoxin, benzamil or thapsigargin did not alter the ATP-induced Na+ influx. The mechanisms that regulate ion and fluid transport by the human intrahepatic bile duct have not been well defined.
Human intrahepatic biliary cell l Cited by: Keppens, S. and De Wulf, H.,Characterization of the liver P 2-purinoceptor involved in the activation of glycogen phosphorylase. Biochemical Journal,– PubMed Google ScholarAuthor: G. Burnstock.
However, the characterization of P 2-purinoceptor subtypes is hampered by an unavailability of potent, highly selective, competitive antagonists.
In the search for selective P 2 -purinoceptor antagonists, the structure-activity relationships for a series of analogues of pyridoxalphosphate and suramin at P 2 -purinoceptor subtypes were investigated in our by: Here we report the genomic cloning and characterization of a gene encoding a new P2 purinoceptor subtype that is exclusively expressed in pancreas.
The identification of a pancreas-specific P2 purinoceptor is especially of interest in view of the reported actions of ADP analogues on insulin secretion via a pharma- cologically defined Pike purinoceptor in pancreas [5,6,21,Cited by: A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text.
Pheochromocytomas are rare, mostly benign tumors of the adrenal medulla whose symptoms are caused by a tumor-induced secretion of catecholamines. This book provides an overview of current knowledge on the clinical situation, diagnosis and therapy of the disease as well as an extensive.
Abstract. The aim of this study was to determine whether 45 Ca 2+ influx could be used as a quantitative measure of channel activation for functional characterisation of P2X purinoceptors in cell lines.
In undifferentiated PC12 cells, grown in suspension, ATP (EC 50 = 45 μM), ATPTS (EC 50 = 50 μM) and 2-meSATP (EC 50 = 81 μM) Cited by: Pheochromocytoma is also capable of causing, at presentation, pseudo-obstruction of bowels, diabetic ketoacidosis, or multisystem crisis involving lactic acidosis.
These symptoms may be in part due to the co-secretion of other hormones associated with norepinephrine, such as corticotropin-releasing hormone, adrenocorticotropin, and interleukin lty: Oncology.
Learn pheochromocytoma with free interactive flashcards. Choose from different sets of pheochromocytoma flashcards on Quizlet. Pheochromocytoma and paragangliomas are neuroendocrine tumors that present with symptoms of hypertension, tachycardia, sweating and anxiety among clinical goal of our program is to establish more effective diagnostic and localization techniques to ensure that no tumor goes undiagnosed as well as to establish new treatment options for this disease.
Discussion. The potency rank of the nucleotides to evoke arterial contraction, α, β-mATP≫ATP>UTP indicates that stimulation of P 2X purinoceptor subtype predominantly mediates contraction (Windscheif et al., ).This suggestion is also supported by the finding that the ATP ( and nmol)-induced arterial contraction was attenuated to some degree by suramin, a P 2 purinoceptor Cited by: 5.
Pheochromocytoma: The Ten-Percent Tumor. Written by James Norman MD, FACS, FACE. Pheochromocytomas are often referred to as the "ten percent tumor" because they do many things about ten percent of the time. The following is a fairly exhaustive list of these characteristics.
Salter MW, Hicks JL. ATP causes release of intracellular Ca2+ via the phospholipase C beta/IP3 pathway in astrocytes from the dorsal spinal cord. J Neurosci. Apr; 15 (4)– Sipma H, den Hertog A, Nelemans A.
The phospholipase C activating P2U purinoceptor also inhibits cyclicAMP formation in DDT1 MF-2 smooth muscle cells. Pheochromocytoma is a rare type of tumor that arises from certain cells known as chromaffin cells, which produce hormones necessary for the body to function properly.
Most pheochromocytomas originate in one of the two adrenal glands located above the kidneys in the back of the upper abdomen. The P2y purinoceptor agonist, 2-methyl-thio-ATP (2-me-S-ATP), had lower affinity (pIC50 = ), while uridine triphosphate, adenosine diphosphate and adenosine, agonists at the P2u, P2t and P1.
P2U receptor transcripts were identified in alkaline phosphatase-positive human bone-derived cells isolated by flow cytometry providing strong evidence for the expression of the P2U purinoceptor. Pheochromocytoma Prognosis. A pheochromocytoma prognosis is a medical opinion concerning the likely outcome in an individual case of the cancer.
A doctor considering a person's prognosis will consider several factors, including the stage of the cancer, where the tumor is located, and the patient's age and general health. Pheochromocytoma are volatile, lethal catecholamine containing tumors of _____ tissue.
1) Chromaffin tissue 2) usually found in adrenal medulla - But occur wherever chromaffin tissue located. Chromaffin cells are modified _____ that receive sympathetic input. 1). The role of different subtypes of P2 purinoceptors on cytosolic Ca2+ level ([Ca2+]i) was examined in vascular smooth muscle of rat aorta.
αβ-Methylene Cited by:. P2U-Purinoceptor Agonists: Emerging Therapy for Pulmonary Diseases, Eduardo R. Lazarowski, William C. Watt, T. Kendall Harden, and Richard C. Boucher Muscarinic Receptor Antagonists Pharmacological and Therapeutic Utility, Richard M.
Eglen NMDA Receptor Antagonists, John A. Kemp and James N. C. Kew New Trends in Drug Design.The P2U-purinoceptor subtype present in these cells is insensitive to PPADS and thus similar to that found in aortic endothelial cells.
Full text Get a printable copy (PDF file) of the complete article (M), or click on a page image below to browse page by by: Thus SPOC1 cells secrete mucin under the control of a P2u purinoceptor; they should prove useful in dissecting the associated cellular regulatory pathways.
Full Text The Full Text of this article is available as a PDF (K).